UMB-32 | B2848

UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent lines. UMB-32 binds to TAF1 and TAF1L with the Kd values of 560 nM and 1.3 μM, respectively.

UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent lines. UMB-32 binds to TAF1 and TAF1L with the Kd values of 560 nM and 1.3 μM, respectively.

B2848 | UMB-32 DataSheet

Alternate Name/Synonyms: N-tert-butyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]imidazo[1,2-a]pyrazin-3-amine; N-(1,1-dimethylethyl)-2-[4-(3,5-dimethyl-4-isoxazolyl)phenyl]-imidazo[1,2-a]pyrazin-3-amine

Appearance: A crystalline solid

Formulation:

CAS Number: 1635437-39-6

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₁H₂₃N₅O

Molecular Weight: 361.44

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~20 mg/ml in ethanol and DMF in 0, ~10 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L

MDL Number:

PubChem CID: 86208116

SMILES: CC1=C(C(=NO1)C)C2=CC=C(C=C2)C3=C(N4C=CN=CC4=N3)NC(C)(C)C

InChi: InChI=1S/C21H23N5O/c1-13-18(14(2)27-25-13)15-6-8-16(9-7-15)19-20(24-21(3,4)5)26-11-10-22-12-17(26)23-19/h6-12,24H,1-5H3

InChi Key: YXPVTKHEWGXKEY-UHFFFAOYSA-N