UNC0321 tri(trifluoroacetate salt) | B2837

UNC0321 is an inhibitor of G9a histone methyltransferase (HMTase) with picomolar potency. It is a quinazoline analogue with a Morrison Ki of 63 pM. It inhibits G9a with an IC₅₀ of 6 nM and 9 nM in chemiluminescence-based oxygen tunneling (CLOT) assays and enzyme-coupled SAH detection assays (ECSD). It inhibits GLP (G9a like protein) with an IC₅₀ of 15 nM and 23 nM in these assays. It is inactive against SET7/9, SET8/PreSET7 and PRMT3 in ECSD assays.

UNC0321 is an inhibitor of G9a histone methyltransferase (HMTase) with picomolar potency. It is a quinazoline analogue with a Morrison Ki of 63 pM. It inhibits G9a with an IC₅₀ of 6 nM and 9 nM in chemiluminescence-based oxygen tunneling (CLOT) assays and enzyme-coupled SAH detection assays (ECSD). It inhibits GLP (G9a like protein) with an IC₅₀ of 15 nM and 23 nM in these assays. It is inactive against SET7/9, SET8/PreSET7 and PRMT3 in ECSD assays.

B2837 | UNC0321 tri(trifluoroacetate salt) DataSheet

Alternate Name/Synonyms: 7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, tri(trifluoroacetate) salt

Appearance:

Formulation: A solution in methyl acetate

CAS Number: n/a

Structure Available?: true

Peptide sequence:

Salt Form: False

Molecular Formula: C₃₃H₄₈F₉N₇O₉

Molecular Weight: 857.76

Cell-Permeable?: True

Purity: ≥95%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of G9a HMTase

MDL Number:

PubChem CID:

SMILES: CN1CCC(NC2=C3C=C(OC)C(OCCOCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

InChi: InChI=1S/C27H45N7O3.3C2HF3O2/c1-31(2)15-16-36-17-18-37-25-20-23-22(19-24(25)35-5)26(28-21-7-11-33(4)12-8-21)30-27(29-23)34-10-6-9-32(3)13-14-34;3*3-2(4,5)1(6)7/h19-21H,6-18H2,1-5H3,(H,28,29,30);3*(H,6,7)

InChi Key: FEROTKYRPUJIEB-UHFFFAOYSA-N