UNC0379 | 9588

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC₅₀ = 7.3 µM; Kd = 18.3 µM). It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC₅₀s = >100 µM).

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC₅₀ = 7.3 µM; Kd = 18.3 µM). It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC₅₀s = >100 µM).

9588 | UNC0379 DataSheet

Alternate Name/Synonyms: 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1620401-82-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₃₅N₅O₂

Molecular Weight: 413.56

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective, substrate-competitive inhibitor of the lysine methyltransferase SET8

MDL Number: N/A

PubChem CID: 78357767

SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC

InChi: InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26)

InChi Key: WEXCGGWTIDNVNT-UHFFFAOYSA-N