UNC13B Antibody (Center) [AMM05462G]

UNC13B Antibody (Center) [AMM05462G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.

Cellular Localisation: Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Cell junction, synapse. Note=Localized to synapses Translocated to the plasma membrane in response to phorbol ester binding (By similarity) .

Molecular Weight: 180679

Clone: Polyclonal

Gene Name: UNC13B (HGNC:12566)

Gene ID: 10497

Function: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity) . Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) . In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity) .

Summary: Tissue Location: Expressed in kidney cortical epithelial cells and brain.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13