LBD
USH1C Antibody (N-term) [APR13927G]
- SKU:
- LBD-APR13927G
- Availability:
- Usually ships in 5 working days
Description
USH1C Antibody (N-term) [APR13927G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This USH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USH1C.
Cellular Localisation: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Colocalizes with F-actin (By similarity) . Detected at the tip of cochlear hair cell stereocilia (By similarity) . Enriched in microvilli of the intestinal brush border (PubMed:24725409) . {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409}
Molecular Weight: 62211
Clone: Polyclonal
Gene Name: USH1C
Gene ID: 10083
Function: Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity) . As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018) .
Summary: Tissue Location: Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Harmonin, Antigen NY-CO-38/NY-CO-37, Autoimmune enteropathy-related antigen AIE-75, Protein PDZ-73, Renal carcinoma antigen NY-REN-3, Usher syndrome type-1C protein, USH1C, AIE75