USP11 polyclonal Antibody | BS91409

USP11 polyclonal Antibody | BS91409 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IP FC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 FC:1:50-1:100

Background: The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: USP11 polyclonal Antibody detects endogenous levels of USP11 protein.

Molecular Weight: 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: USP11, UHX1, Deubiquitinating enzyme 11, Ubiquitin carboxyl-terminal hydrolase 11, Ubiquitin carboxyl-terminal hydrolase X linked, ubiquitin specific peptidase 11, Ubiquitin specific protease 11, Ubiquitin thiolesterase 11, Ubiquitin-specific-processing protease 11, UBP11, UHX1, USP11,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: