USP12 Antibody (C-term) [APR04819G]

USP12 Antibody (C-term) [APR04819G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This USP12/USP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-345 amino acids from the C-terminal region of human USP12/USP46.

Cellular Localisation: N/A

Molecular Weight: 42858

Clone: Polyclonal

Gene Name: USP12

Gene ID: 219333

Function: Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336) . Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014) . In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Ubiquitin carboxyl-terminal hydrolase 12, Deubiquitinating enzyme 12, Ubiquitin thioesterase 12, Ubiquitin-hydrolyzing enzyme 1, Ubiquitin-specific-processing protease 12, USP12, UBH1, USP12L1