USP14 Inhibitor, IU1 | 1845

A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM.

USP14 Inhibitor, IU1 is a cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM.

1845 | USP14 Inhibitor, IU1 DataSheet

Alternate Name/Synonyms: 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 314245-33-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₁FN₂O

Molecular Weight: 300.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A USP14 inhibitor

MDL Number: MFCD01917473

PubChem CID: 675434

SMILES: CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3

InChi: InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3

InChi Key: JUWDSDKJBMFLHE-UHFFFAOYSA-N