LBD
USP51 Antibody (Center) [APR04587G]
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- LBD-APR04587G
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Description
USP51 Antibody (Center) [APR04587G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This USP51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-307 amino acids from the Central region of human USP51.
Cellular Localisation: Chromosome. Note=Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair.
Molecular Weight: 79756
Clone: Polyclonal
Gene Name: USP51 (HGNC:23086)
Gene ID: 158880
Function: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys- 16' (H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998) . USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998) .
Summary: Tissue Location: Expressed in prostate, brain, lung, aorta and kidney.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, IF
Dilution: WB--1:1000
Synonyms: Ubiquitin carboxyl-terminal hydrolase 51, Deubiquitinating enzyme 51, Ubiquitin thioesterase 51, Ubiquitin-specific-processing protease 51, USP51