VDR Antibody| F40380-0.08ML/F40380-0.4ML/R31945

VDR Antibody| F40380-0.08ML/F40380-0.4ML/R31945 | Gentaur UK, US & Europe Distribution

Background: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Format: Purified

Clone: 517CT23.5.1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgA

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:100-1:500

Application Note: Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This VDR antibody is available for research use only.

Purity: Purified

Immunogen: Purified His-tagged protein fragment was used to produced this monoclonal VDR antibody.

Storage: Aliquot the VDR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A