VPS26 polyclonal Antibody | BS91442

VPS26 polyclonal Antibody | BS91442 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC IP

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 IP:1:10-1:50

Background: Acts as component of the retromer cargo-selective complex (CSC) . The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) . Required for the endosomal localization of WASHC2A (indicative for the WASH complex) . Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: VPS26 polyclonal Antibody detects endogenous levels of VPS26 protein.

Molecular Weight: 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hVPS26, VPS26A, VPS26, FLJ12930, HB 58, HB58, Hbeta 58, Hbeta 58 homolog, Hbeta58, Hbeta58 homolog, hVPS 26, hVPS26, MGC94168, PEP 8A, PEP8A, Vacuolar protein sorting 26 A, Vacuolar protein sorting 26, Vacuolar protein sorting 26 homolog A, Vacuolar protein sorting 26 homolog A S. pombe, Vacuolar protein sorting 26 homolog A yeast, Vacuolar protein sorting 26 yeast, Vacuolar protein sorting 26 yeast homolog, Vacuolar protein sorting 26A, Vacuolar protein sorting associated protein 26A, Vacuolar protein sorting-associated protein 26A, Vesicle protein sorting 26, Vesicle protein sorting 26A, VP26A, VPS 26, VPS 26A, VPS26A,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: Adherens Junction signaling,