WDR51B Antibody (C-term) [APR03518G]

WDR51B Antibody (C-term) [APR03518G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This WDR51B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-350 amino acids from the C-terminal region of human WDR51B.

Cellular Localisation: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles (PubMed:32060285) . Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. {ECO:0000250|UniProtKB:Q8BHD1, ECO:0000269|PubMed:32060285}

Molecular Weight: 53668

Clone: Polyclonal

Gene Name: POC1B (HGNC:30836)

Gene ID: 282809

Function: Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285) . Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428) . Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285) . Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594) . Required for retinal integrity (PubMed:25044745) .

Summary: Tissue Location: Expressed in the retina.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: POC1 centriolar protein homolog B, Pix1, Proteome of centriole protein 1B, WD repeat-containing protein 51B, POC1B, WDR51B