WHI-P180 | B2908

WHI-P180 is a multi-kinase inhibitor. It inhibits human proto-oncogene receptor tyrosine kinase RET (Rearranged during Transfection) and kinase insert domain receptor (KDR) with IC₅₀ values of 4.5 nM and 66 nM respectively. It inhibits epidermal growth factor receptor (EGFR) kinase with an IC₅₀ of 4.0 μM and also inhibits Janus kinase 3 (JAK3). It exhibits potent anti-graft-versus-host disease activity and IgE-mediated mast cell responses in vitro and in vivo.

WHI-P180 is a multi-kinase inhibitor. It inhibits human proto-oncogene receptor tyrosine kinase RET (Rearranged during Transfection) and kinase insert domain receptor (KDR) with IC₅₀ values of 4.5 nM and 66 nM respectively. It inhibits epidermal growth factor receptor (EGFR) kinase with an IC₅₀ of 4.0 μM and also inhibits Janus kinase 3 (JAK3). It exhibits potent anti-graft-versus-host disease activity and IgE-mediated mast cell responses in vitro and in vivo.

B2908 | WHI-P180 DataSheet

Alternate Name/Synonyms: 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol; 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline; Janex3; 4-(3'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline

Appearance: A crystalline solid

Formulation:

CAS Number: 211555-08-7

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₆H₁₅N₃O₃

Molecular Weight: 297.31

Cell-Permeable?: True

Purity: >98%

Solubilities: ~15 mg/ml in in DMSO, ~25 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A multi-kinase inhibitor

MDL Number:

PubChem CID: 5687

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)O)OC

InChi: InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)

InChi Key: