WISP2 Polyclonal Antibody | E-AB-53562

WISP2 Polyclonal Antibody | E-AB-53562 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: CCN family member 5, CCN5, Connective tissue growth factor like protein, Connective tissue growth factor related protein 58, Connective tissue growth factor-like protein, Connective tissue growth factor-related protein 58, CT58, CTGF L, CTGF-L, WISP 2, WISP-2, Wisp2, WISP2, Wnt 1 signaling pathway protein 2, WNT1 inducible signaling pathway protein 2, WNT1-inducible-signaling pathway protein 2

Application: IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Stem Cells

Background: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

Concentration: 0.8 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human WISP2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A