WNK1 polyclonal Antibody | BS91451

WNK1 polyclonal Antibody | BS91451 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: WNK1 polyclonal Antibody detects endogenous levels of WNK1 protein.

Molecular Weight: 250/300 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: p65, hWNK1, WNK1, HSN2, KDP, KIAA0344, PRKWNK1, Erythrocyte 65 kDa protein, HSAN2, HSN2, hWNK1, KDP, KIAA0344, Kinase deficient protein, MGC163339, MGC163341, p65, PPP1R167, PRKWNK1, Prostate derived sterile 20 like kinase, Protein kinase lysine deficient 1, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, Protein phosphatase 1, regulatory subunit 167, PSK, Serine/threonine protein kinase WNK1 1, Serine/threonine protein kinase WNK1 2, Serine/threonine protein kinase WNK1, Serine/threonine-protein kinase WNK1, With no K, WNK lysine deficient protein kinase 1, WNK lysine deficient protein kinase 1 isoform, WNK1, WNK1,

Immunogen: Synthetic peptide within Human WNK1 aa 100-200 (Cysteine residue) .

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: