WWOX (A7) polyclonal Antibody | BS2426

WWOX (A7) polyclonal Antibody | BS2426 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: WWOX (WW domain containing oxidoreductase) protein is a candidate tumor suppressor consisting of two WW domains that influence protein-protein interactions, and a short chain dehydrogenase (SDR) domain, that influences sex-steroid metabolism. Modulation of the WWOX gene influences esophageal squamous cell carcinogenesis and tumorigenicity of breast cancer cell lines MDA-MB-435 and T47D. The murine homolog WOX1 localizes in the mitochondria, and contains a mitochondrial targeting sequence mapping within the SDR domain. JNK1 can physically associate with WOX1 and sequester WOX1-dependent apoptosis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: WWOX (A7) polyclonal Antibody detects endogenous levels of WWOX protein.

Molecular Weight: ~ 47 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase; WWOX; FOR; WOX1

Immunogen: Synthetic peptide, corresponding to the N-terminual of Human WWOX.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Immune Cell Signaling,Jak Stat ：IL-6 Receptor Signaling,T cell receptor signaling,