Xanthohumol | 2258

Cell-permeable. A bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II). Impairs prostate cancer cell growth and proliferation.

Xanthohumol is a bioactive flavonoid antioxidant found in the flowering hops plant. Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II).

2258 | Xanthohumol DataSheet

Alternate Name/Synonyms: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)- 2-propen-1-one

Appearance: Yellow solid

Formulation: N/A

CAS Number: 6754-58-1

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₂₁H₂₂O₅

Molecular Weight: 354.4

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~35 mg/ml) or EtOH (~35 mg/ml)

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: Valosin-containing protein (VCP) inhibitor

MDL Number: MFCD00210576

PubChem CID: 639665

SMILES: CC(=CCC1=C(C=C(C(=C1O)C(=O)C=CC2=CC=C(C=C2)O)OC)O)C

InChi: InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+

InChi Key: ORXQGKIUCDPEAJ-YRNVUSSQSA-N