XRCC1 Antibody (Center) [APR10935G]

XRCC1 Antibody (Center) [APR10935G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.

Cellular Localisation: Nucleus. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage

Molecular Weight: 69477

Clone: Polyclonal

Gene Name: XRCC1

Gene ID: 7515

Function: Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP- ribosyltransferase PARP1 activity.

Summary: Tissue Location: Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC, IF

Dilution: IF--1:25 WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1