XRCC6 (Acetyl-K338) polyclonal Antibody | BS64099

XRCC6 (Acetyl-K338) polyclonal Antibody | BS64099 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: The Ku protein islocalized in the nucleus and iscomposed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) . Ku wasfirst described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and waslater found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cellsignaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription byvirtue of its DNA binding activity,serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer binding factor (E1BF),composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: XRCC6 (Acetyl-K338) polyclonal Antibody detects endogenous levels of XRCC6 protein only when acetylated at Lys338.

Molecular Weight: ~ 69 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; XRCC6

Immunogen: Synthetic Acetylated peptide derived from human XRCC6 around the Acetylation site of lysine K338.

Conjugate: Unconjugated

Modification: Acetylated

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Microtubule Dynamics,