XRN1 Antibody [AMM22202G]

XRN1 Antibody [AMM22202G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This XRN1 antibody is generated from a mouse immunized with arecombinant protein between1455-1706 amino acids from human XRN1.

Cellular Localisation: Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane

Molecular Weight: 194107

Clone: Monoclonal

Gene Name: XRN1

Gene ID: 54464

Function: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity) . Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) .

Summary: Tissue Location: Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: 5'-3' exoribonuclease 1, 3.1.13.-, Strand-exchange protein 1 homolog, XRN1, SEP1