YARS Antibody | 22-489

YARS Antibody | 22-489 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human YARS (NP_003671.1) .

Research Area: Apoptosis, Cell Cycle, Chemokines & Cytokines, Immunology

Tested Application: WB, IP

Application: WB: 1:500 - 1:2000
IP: 1:50 - 1:200

Specificiy: N/A

Positive Control 1: HeLa

Positive Control 2: SKOV3

Positive Control 3: Mouse brain

Positive Control 4: Mouse skeletal muscle

Positive Control 5: Rat brain

Positive Control 6: N/A

Molecular Weight: Observed: 59kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: YARS, YRS, YTS, TYRRS, CMTDIC

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.