YARS polyclonal Antibody | BS8444

YARS polyclonal Antibody | BS8444 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Tryptophanyl-tRNA synthetases are essential enzymes that catalyze the aminoacylation of tRNA (Trp) with tryptophan, an essential function of the cell’s protein synthesis machinery. Two forms of tryptophanyl-tRNA synthetase exist; a cytoplasmic form, named TrpRS (also known as WARS), and a mitochondrial form, named WARS2. In normal cells, human TrpRS exists as a full length form and as a truncated form designated mini TrpRS, which is produced by alternative splicing. Expression of mini TrpRS is highly stimulated in human cells by the addition of IFN-g. Although both human full length TrpRS and mini TrpRS are enzymatically active in aminoacylation, they differ in angiostatic activity. The tyrosyl-tRNA synthetase (TyrRS), a protein related to TrpRS, exists as a homodimeric enzyme that catalyzes the aminoacylation of tRNA (Tyr) by L-tyrosine.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: YARS polyclonal Antibody detects endogenous levels of YARS protein.

Molecular Weight: ~ 59 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Tyrosine--tRNA ligase, cytoplasmic; Tyrosyl-tRNA synthetase; TyrRS; YARS

Immunogen: Recombinant full length Human YARS.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: