YC-1 | 2061

Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.

YC-1 is a nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor.

2061 | YC-1 DataSheet

Alternate Name/Synonyms: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole

Appearance: White to pale yellow solid

Formulation: N/A

CAS Number: 170632-47-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₁₆N₂O₂

Molecular Weight: 304.34

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (100 mM) or EtOH (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A soluble guanylyl cyclase (sGC) activator

MDL Number: MFCD06407798

PubChem CID: 5712

SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO

InChi: InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20- 19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2

InChi Key: OQQVFCKUDYMWGV-UHFFFAOYSA-N