YK-3-237 | B2762

YK-3-237 is a sirtuin 1(SIRT1) activator. It activates SIRT1 in a concentration-dependent manner and reduces acetylation of wild-type and mutant p53 in a SIRT1-dependent manner YK-3-237 inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = <0.01-20.9 μM).

YK-3-237 is a sirtuin 1(SIRT1) activator. It activates SIRT1 in a concentration-dependent manner and reduces acetylation of wild-type and mutant p53 in a SIRT1-dependent manner YK-3-237 inhibits cell growth in a panel of leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast cancer cell lines (GI50s = <0.01-20.9 μM).

B2762 | YK-3-237 DataSheet

Alternate Name/Synonyms: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid

Appearance: Yellow solid

Formulation:

CAS Number: 1215281-19-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₁BO₇

Molecular Weight: 372.18

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml Ethanol; >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A sirtuin 1 (SIRT1) activator

MDL Number:

PubChem CID: 24881094

SMILES: O=C(/C=C/C1=CC=C(OC)C(B(O)O)=C1)C2=CC(OC)=C(OC)C(OC)=C2

InChi: InChI=1S/C19H21BO7/c1-24-16-8-6-12(9-14(16)20(22)23)5-7-15(21)13-10-17(25-2)19(27-4)18(11-13)26-3/h5-11,22-23H,1-4H3/b7-5+

InChi Key: AKNGHUAJAODDJA-FNORWQNLSA-N