Z-AEVD-FMK | B1162

Z-AEVD-FMK is a synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-AEVD-FMK is a synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

B1162 | Z-AEVD-FMK DataSheet

Alternate Name/Synonyms: Z-A-E(OMe)-V-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK; Z-Ala-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; FK033

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: 1135688-47-9

Structure Available?: Yes

Peptide sequence: Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK

Salt Form: No

Molecular Formula: C₂₈H₃₉FN₄O₁₀

Molecular Weight: 610.63

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A caspase-10 inhibitor

MDL Number: MFCD03453601

PubChem CID: 25108694

SMILES: CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1

InChi Key: CHZRBQFKZDGMTP-CDSYHYPYSA-N