Z-YVAD-FMK | 1141

A synthetic peptide that irreversibly inhibits activity of caspase-1. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-YVAD-FMK is a cell-permeable, irreversible caspase-1 inhibitor.

1141 | Z-YVAD-FMK DataSheet

Alternate Name/Synonyms: Z-YVAD-FMK, Z-YVAD-fluoromethylketone, Caspase-1 Inhibitor (fluoromethylketone)

Appearance: Lyophilized solid

Formulation: N/A

CAS Number: N/A

Structure Available?: No

Peptide sequence: Z-Tyr-Val-Ala-Asp(OMe)-FMK

Salt Form: No

Molecular Formula: C₃₁H₃₉FN₄O₉

Molecular Weight: 630.7

Cell-Permeable?: Yes

Purity: Single spot by TLC

Solubilities: DMSO (20 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A caspase-1 inhibitor

MDL Number: N/A

PubChem CID: 16760349

SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2

InChi: InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32) 15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21- 8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34, 40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1

InChi Key: MVPQJUFFTWWKBT-UYDLRUHXSA-N