Zanubrutinib | B2512

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; displaysmuch more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib. BGB-3111 selectively binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor; displaysmuch more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib. BGB-3111 selectively binds to and inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.

B2512 | Zanubrutinib DataSheet

Alternate Name/Synonyms: (7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; BGB-3111; (S)-Zanubrutinib; BGB3111

Appearance: White to off-white solid

Formulation:

CAS Number: 1691249-45-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₉N₅O₃

Molecular Weight: 471.56

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, selective and orally available Btk inhibitor

MDL Number:

PubChem CID: 135905454

SMILES: C=CC(=O)N1CCC(CC1)C2CCNC3=C(C(=NN23)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=O)N

InChi: InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-27-24(26(28)34)25(30-32(22)27)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18,22,29H,1,12-17H2,(H2,28,34)

InChi Key: RNOAOAWBMHREKO-UHFFFAOYSA-N