ZGPAT Antibody | 6611

ZGPAT Antibody | 6611 | Gentaur UK, US & Europe Distribution

Host: Chicken

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Sheep: (100%) , Bovine: (100%)

Immunogen: ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT.
The immunogen is located within the last 50 amino acids of ZGPAT.

Research Area: Cancer, Cell Cycle

Tested Application: E, WB, IF

Application: ZGPAT antibody can be used for detection of ZGPAT by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: Multiple isoforms of ZGPAT are known to exist.

Positive Control 1: Cat. No. 1220 - SK-N-SH Cell Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: ZGPAT Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgY

Conjugate: Unconjugated

Physical State: Liquid

Buffer: ZGPAT Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: ZGPAT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: ZGPAT Antibody: ZIP, ZC3H9, GPATC6, GPATCH6, ZC3HDC9, KIAA1847, ZIP, Zinc finger CCCH-type with G patch domain-containing protein, G patch domain-containing protein 6

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) , is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.