ZLN005 | 2550

ZLN005 is a small molecule transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. ZLN005 increases fat oxidation and improves the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice.

ZLN005 is a small molecule transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM.

2550 | ZLN005 DataSheet

Alternate Name/Synonyms: 2-(4-tert-Butylphenyl)-1H-benzimidazole, 2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazole

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 49671-76-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₈N₂

Molecular Weight: 250.34

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~ 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Atranscriptional regulator of PGC1-α

MDL Number: N/A

PubChem CID: 899323

SMILES: CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2

InChi: InChI=1S/C17H18N2/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H,1-3H3,(H,18,19)

InChi Key: LQUNNCQSFFKSSK-UHFFFAOYSA-N