ZM 447439 | 2018

Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC₅₀ > 10 μM).

ZM 447439 is a selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC₅₀ > 10 μM).

2018 | ZM 447439 DataSheet

Alternate Name/Synonyms: N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

Appearance: Orange solid

Formulation: N/A

CAS Number: 331771-20-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₃₁N₅O₄

Molecular Weight: 513.59

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Aurora B kinase inhibitor

MDL Number: MFCD08703125

PubChem CID: 9914412

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)NC(=O)C4=CC=CC=C4)OCCCN5CCOCC5

InChi: InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37- 17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/ h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)

InChi Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N