Cell-permeable. A selective, ATP-competitive inhibitor of Aurora B kinase in vitro (IC₅₀ values are 50 nM, 250 nM and 1 μM for Aurora B, C and A kinases respectively). Selective over a range of other...
Cell-permeable. A potent, selective and ATP-competitive inhibitor of c-Raf in vitro (IC₅₀ = 70 nM for inhibition of human c-Raf). Displays 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38...