ZSTK474 | 1597

ZSTK474 is a reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI3K) isoforms ((IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). More effective than LY 294,002 in vitro and as in vivo. Displays strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice.

ZSTK474 is a reversible, potent and specific inhibitor of phosphoinositide 3-kinase (PI3K) isoforms ((IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). More effective than LY 294,002 in vitro and as in vivo. Displays strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice.

1597 | ZSTK474 DataSheet

Alternate Name/Synonyms: 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine

Appearance: White solid

Formulation: N/A

CAS Number: 475110-96-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₂₁F₂N₇O₂S

Molecular Weight: 417.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and specific phosphoinositide 3-kinase (PI3K) inhibitor

MDL Number: N/A

PubChem CID: 11647372

SMILES: C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5

InChi: InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2

InChi Key: HGVNLRPZOWWDKD-UHFFFAOYSA-N