1,10-Phenanthroline | B3122

1,10-Phenanthroline is a metal chelator and inhibitor of metalloproteases. 1,10-Phenanthrine acts as a fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner. It reduces the expression of matrix metalloproteinase (MMP3) during chondrogenic differentiation of human chondrocytes.

1,10-Phenanthroline is a metal chelator and inhibitor of metalloproteases. 1,10-Phenanthrine acts as a fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner. It reduces the expression of matrix metalloproteinase (MMP3) during chondrogenic differentiation of human chondrocytes.

B3122 | 1,10-Phenanthroline DataSheet

Alternate Name/Synonyms: 2-Phenanthroline; 4,5-Diazaphenanthrene; o-Phenanthroline; 5,6-dihydro-1,10-phenanthroline

Appearance: Off-white solid

Formulation:

CAS Number: 66-71-7

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₂H₈N₂

Molecular Weight: 180.2

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities: ~18 mg/ml in DMSO or Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A metal chelator and inhibitor of metalloproteases

MDL Number: MFCD00011678

PubChem CID: 1318

SMILES: C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1

InChi: InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H

InChi Key: DGEZNRSVGBDHLK-UHFFFAOYSA-N