1,4-DPCA | B3123

1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4 µM, respectively. It also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM. Inhibitors of prolyl 4-hydroxylase maybe useful in controlling excess collagen deposition in pathological fibrosis.

1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4 µM, respectively. It also inhibits factor inhibiting HIF (FIH) with an IC₅₀ of 60 μM. Inhibitors of prolyl 4-hydroxylase maybe useful in controlling excess collagen deposition in pathological fibrosis.

B3123 | 1,4-DPCA DataSheet

Alternate Name/Synonyms: 4-oxo-1H-1,10-phenanthroline-3-carboxylic acid; 4-Oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid; 3-Acetyl-1H-[1,10]phenanthrolin-4-one; 4-Hydroxy-1,10-phenanthroline-3-carboxylic acid

Appearance: Light brown powder

Formulation:

CAS Number: 331830-20-7, 53946-49-9

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₃H₈N₂O₃

Molecular Weight: 240.21

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities: ~3 mg/ml in DMSO or DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A competitive inhibitor of prolyl 4-hydroxylase

MDL Number: MFCD07357380

PubChem CID: 459803

SMILES: C1=CC2=C(C3=C(C=C2)C(=O)C(=CN3)C(=O)O)N=C1

InChi: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18)

InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N