10-Hydroxycamptothecin | B1995

10-Hydroxycamptothecin is a potent topoisomerase I inhibitor. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound (Cat. No. 1039). 10-Hydroxycamptothecin displays strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM).

10-Hydroxycamptothecin is a potent topoisomerase I inhibitor. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound (Cat. No. 1039). 10-Hydroxycamptothecin displays strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM).

B1995 | 10-Hydroxycamptothecin DataSheet

Alternate Name/Synonyms: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC107124

Appearance: White solid

Formulation: N/A

CAS Number: 19685-09-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₆N₂O₅

Molecular Weight: 364.35

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent topoisomerase I inhibitor

MDL Number: MFCD00189425

PubChem CID: 97226

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

InChi: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

InChi Key: HAWSQZCWOQZXHI-FQEVSTJZSA-N