10058-F4 | 2739

10058-F4 is a c-Myc inhibitor that inhibits the c-Myc-Max associationn and function. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia. 10058-F4 inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells.

10058-F4 is a c-Myc inhibitor that inhibits the c-Myc-Max associationn and function. It prevents the growth of fibroblasts in a c-Myc-dependent manner. 10058-F4 downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia.

2739 | 10058-F4 DataSheet

Alternate Name/Synonyms: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

Appearance: Yellow solid

Formulation: N/A

CAS Number: 403811-55-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₁NOS₂

Molecular Weight: 249.35

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (60 mg/ml) or EtOH (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A c-Myc inhibitor

MDL Number: MFCD00758517

PubChem CID: 1271002

SMILES: CCC1=CC=C(C=C1)C=C2C(=O)NC(=S)S2

InChi: InChI=1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChi Key: SVXDHPADAXBMFB-JXMROGBWSA-N