12-Deoxywithastramonolide | B2768

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots that displays anti-inflammatory activity, reducing TNF-α and increasing IL-10 production in mice 12-Deoxywithastramonolide also reduces the growth of A549 lung and HT-29 colorectal cancer cells (IC50s = 47.1 and 29.8 μM, respectively).

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots that displays anti-inflammatory activity, reducing TNF-α and increasing IL-10 production in mice 12-Deoxywithastramonolide also reduces the growth of A549 lung and HT-29 colorectal cancer cells (IC50s = 47.1 and 29.8 μM, respectively).

B2768 | 12-Deoxywithastramonolide DataSheet

Alternate Name/Synonyms: 27-Hydroxywithanolide B,6α,7α-epoxy-5α,22R,27-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone

Appearance: Crystalline solid

Formulation:

CAS Number: 60124-17-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₈O₆

Molecular Weight: 470.6

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~15 mg/ml Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An anti-inflammatory compound

MDL Number:

PubChem CID: 44576309

SMILES: CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3C5C(O5)C6(C4(C(=O)C=CC6)C)O)C)CO

InChi: InChI=1S/C28H38O6/c1-14-12-20(33-25(31)16(14)13-29)15(2)17-7-8-18-22-19(9-11-26(17,18)3)27(4)21(30)6-5-10-28(27,32)24-23(22)34-24/h5-6,15,17-20,22-24,29,32H,7-13H2,1-4H3/t15-,17+,18-,19-,20+,22-,23-,24-,26+,27-,28-/m0/s1

InChi Key: AWVMHXZWAKRDGG-MEBIVHGNSA-N