14-3-3 Theta polyclonal Antibody | BS90004

14-3-3 Theta polyclonal Antibody | BS90004 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF FC

Application Range: WB:1:1,000-1:5,000 ICC:1:100-1:500 FC:1:50-1:100

Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: 14-3-3 Theta polyclonal Antibody detects endogenous levels of 14-3-3 Theta protein.

Molecular Weight: 28 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: YWHAQ, 14-3-3, 14-3-3 protein T-cell, 14-3-3 protein tau, 14-3-3 protein theta, 1C5, HS1, theta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta isoform, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: