1400W dihydrochloride | 2055

Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Kᵢ values of 2 and 50 µM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices.

1400W dihydrochloride is a slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with Kᵢ values of 2 and 50 µM respectively. I

2055 | 1400W dihydrochloride DataSheet

Alternate Name/Synonyms: N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 214358-33-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₅N₃ . 2HCl

Molecular Weight: 250.17

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: Water (100 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A highly selective iNOS inhibitor

MDL Number: MFCD03428622

PubChem CID: 2733515

SMILES: CC(=NCC1=CC(=CC=C1)CN)N.Cl.Cl

InChi: InChI=1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H

InChi Key: WDJHSQZCZGPGAA-UHFFFAOYSA-N