2-Arachidonoylglycerol | B2992

2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid G-protein coupled receptors (CB1 and CB2) with Ki values of 472 nM and 1400 nM respectively. 2-arachidonoylglycerol induces a rapid, transient increase in intracellular free calcium in NG108-15 cells at a concentration of 0.3 nM, through a CB1 receptor-dependent mechanism. It is present at relatively high levels in the brain when compared to anandamide.

2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid G-protein coupled receptors (CB1 and CB2) with Ki values of 472 nM and 1400 nM respectively. 2-arachidonoylglycerol induces a rapid, transient increase in intracellular free calcium in NG108-15 cells at a concentration of 0.3 nM, through a CB1 receptor-dependent mechanism. It is present at relatively high levels in the brain when compared to anandamide.

B2992 | 2-Arachidonoylglycerol DataSheet

Alternate Name/Synonyms: 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate; Glyceryl 2-arachidonate; (5Z,8Z,11Z,14Z)-1,3-dihydroxypropan-2-yl icosa-5,8,11,14-tetraenoate

Appearance: Colorless Solution

Formulation: A solution in acetonitrile (as a 9:1 mixture of the 2-AG and 1-AG)

CAS Number: 53847-30-6

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₃H₃₈O₄

Molecular Weight: 378.55

Cell-Permeable?: False

Purity: ≥95%

Solubilities: ~150 μg/ml in PBS, pH 7.2, ~10 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An endocannabinoid and an agonist of CB1 and CB2

MDL Number: MFCD01862600

PubChem CID: 5282280

SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC(CO)CO

InChi: InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-

InChi Key: RCRCTBLIHCHWDZ-DOFZRALJSA-N