2-Deoxy-D-Glucose | B1048

2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.

2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism.

B1048 | 2-Deoxy-D-Glucose DataSheet

Alternate Name/Synonyms: 2-Deoxy-D-arabinohexose, 2-Deoxyglucose

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 154-17-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₁₂O₅

Molecular Weight: 164.16

Cell-Permeable?: Yes

Purity: ≥98% GC

Solubilities: H2O (>15 mg/ml) or DMSO (>15 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A competitive inhibitor of glucose metabolism.

MDL Number: MFCD00151328

PubChem CID: 439268

SMILES: C1C(C(C(OC1O)CO)O)O

InChi: InChI=1S/C6H12O5/c7-2-4-6(10)3(8)1-5(9)11-4/h3-10H,1-2H2/t3-,4-,5?,6+/m1/s1

InChi Key: PMMURAAUARKVCB-CERMHHMHSA-N