2-Guanidinobenzimidazole | B3130

2-Guanidinobenzimidazole is an inhibitor of voltage-gated proton channel Hv1. It inhibits Hv1 proton conduction (10 μM-200 μM) by binding to the voltage-sensing domain. Inhibition of excessive Hv1 activity could be beneficial in ischemic stroke and cancer.

2-Guanidinobenzimidazole is an inhibitor of voltage-gated proton channel Hv1. It inhibits Hv1 proton conduction (10 μM-200 μM) by binding to the voltage-sensing domain. Inhibition of excessive Hv1 activity could be beneficial in ischemic stroke and cancer.

B3130 | 2-Guanidinobenzimidazole DataSheet

Alternate Name/Synonyms: 2GBI; 2-(1H-benzimidazol-2-yl)guanidine; (benzimidazol-2-ylamino)methanamidine

Appearance: Off-white powder

Formulation:

CAS Number: 5418-95-1

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₈H₉N₅

Molecular Weight: 175.19

Cell-Permeable?: TRUE

Purity: ≥ 95% by SDS-PAGE

Solubilities: ~50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of voltage-gated proton channel Hv1

MDL Number: MFCD00005590

PubChem CID: 36149

SMILES: C1=CC=C2C(=C1)NC(=N2)N=C(N)N

InChi: InChI=1S/C8H9N5/c9-7(10)13-8-11-5-3-1-2-4-6(5)12-8/h1-4H,(H5,9,10,11,12,13)

InChi Key: JJWCTKUQWXYIIU-UHFFFAOYSA-N