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ARRY-380 analog is an inhibitor of EGFR (ErbB1).ARRY-380 analog is an inhibitor of EGFR (ErbB1).B3219 | ARRY-380 analog DataSheetAlternate Name/Synonyms:...

ARRY-797 is a potent and selective p38 mitogen-activated protein kinase inhibitor. Inhibits LPS-Induced IL-6 and In Vivo Growth of RPMI-8226 Human Multiple Myeloma Cells.ARRY-797 is a potent and...

Human Artemin, a neurotrophic factor, belongs to the GDNF family. Artemin is a survival factor for sensory and sympathetic neurons in culture. Recombinant human Artemin is a 24.2 kDa,...

3307BP | Artemis Blocking Peptide DataSheetAntibody Target: ArtemisAccession #: Q96SD1Gene ID: 64421Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3307 | Artemis (DCLREIC) Antibody DataSheet

Artemisinin is a sesquiterpene natural product originally isolated from plants of the genus Artemisia. It effectively kills malarial parasites of the genus Plasmodium (IC₅₀ = 4.0 nM). Displays...

Artesunate is a semisynthetic derivative of artemisinin. It acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane...

E4349 | Artrial Natruireitc Peptide ANP Elisa Kit DataSheet

ARV-771 | B3368Description: ARV-771 is a potent BET bromodomain PROTAC® degrader with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and...

ARV-825 is a BRD4 inhibitor. It is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged...

AS 602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.AS 602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and...

Cell-permeable. A selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS 604850 inhibits...

AS-041164 is a potent, ATP-competitive, and isoform-selective PI3-Kinase inhibitor (IC₅₀ = 0.07, 0.24, 1.45, and 1.70 μM for the γ, α, β, and δ isoforms respectively).AS-041164 is a potent,...

AS-1517499 | B3357Description: AS-1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor (IC50 = 21 nM). It inhibits IL-4-induced Th2 differentiation (IC50 = 2.3 nM), but not...

AS-1842856 | B3343Description: AS-1842856 is a potent and selective Foxo1 (forkhead box class O transcription factor 1) inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4);...

AS-2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC₅₀ = 21 nM). It exhibits 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and...

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ IC50= 30 nM, PI3Ka IC50=940 nM, PI3Kb IC50=20,000 nM and PI3Kd IC50= 20,000 nM...

3954 | AS160/TBC1 Antibody DataSheet

3954BP | AS160/TBC1 Blocking Peptide DataSheetAntibody Target: AS160/TBC1 Accession #: O60343Gene ID: 9882Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Cell-permeable. AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC₅₀ = 150 nM, hJNK2: IC₅₀ = 220 nM and hJNK3: IC₅₀ = 70 nM). Displays anti-inflammatory properties and has been shown to...

AS8351 is a histone demethylase (HDM) inhibitor and an epigenetic modulator. In combination with eight other small molecules (called 9C), AS8351 enables conversion of human fibroblasts into...

3828 | ASAH2 Antibody DataSheet

3828BP | ASAH2 Blocking Peptide DataSheetAntibody Target: ASAH2 Accession #: Q9NR71Gene ID: 56624Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) ASAH2 peptide in...

A zwitterionic detergent useful for the solubilization of proteins including previously undetected membrane proteins. ASB-14 exhibits better protein solubilization properties than CHAPS. Also useful...

A zwitterionic detergent useful for the solubilization of proteins including previously undetected membrane proteins. ASB-16 exhibits better protein solubilization properties than CHAPS. Also useful...

3291BP | ASC Blocking Peptide DataSheetAntibody Target: ASC Accession #: AAH04470.1Gene ID: 29108Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3291 | ASC/TMS1 Antibody DataSheet

Ascofuranone, a compound isolated from the phytopathogenic fungus, Ascochyta visiae, acts as a potent inhibitor of trypanosome alternative oxidase (TAO). (TAO) is the terminal oxidase of the...

Ascomycin (also known as Immunomycin) is an analog of tacrolimus with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant,...

Ascorbate oxidase is a homodimeric enzyme, which comprises 552 amino acid residues per subunit (zucchini). It corresponds to a molecular mass of 70 kDa per subunit. This enzyme is mainly found in...

K671 | Ascorbic Acid Colorimetric Assay Kit II FRASC DataSheet

K661 | Ascorbic Acid Colorimetric/Fluorometric Assay Kit DataSheet

3772 | ASH2 Antibody DataSheet

6836 | ASH2 polyclonal antibody DataSheet

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or ERK, MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its...

3128 | ASK1/MAPKKK5 Antibody DataSheet

ASN-002 (Gusacitinib) is a potent dual inhibitor of SYK/JAK kinases. ASN-002 displays strong antitumor activity in both hematological and solid tumor xenograft models. ASN-002 strongly suppresses the...

ASP-3026 is a potent, and ATP-competitive inhibitor of ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase) with IC₅₀ value of 3.5 nM. It also inhibits ROS (IC₅₀ = 8.9 nM) and ACK (IC₅₀ = 5.8 nM)...

ASP-4132 is a potent AMPK activator with potential antineoplastic activity. Upon oral administration, ASP4132 affects oxidative phosphorylation in mitochondria of metabolically-active tumor cells,...

ASP7663 is a selective transient receptor potential ankyrin 1 (TRPA1) activator. It activates human, rat and mouse TRPA1 receptors with EC₅₀ values of 510 nM, 540 nM and 500 nM, respectively. It...

K754 | Asparaginase Activity Colorimetric/Fluorometric Assay Kit DataSheet

K736 | Asparagine Assay Kit Colorimetric DataSheet

AST/SGOT is found in many tissues throughout the body, including the liver, heart, muscles, kidney, and brain. If any of these organs or tissues is affected by disease or injury, AST is released into...

There are two SGOT/AST isoenzymes are present in humans, they have high similarity. GOT1, the cytosolic isoenzyme derives mainly from red blood cells and heart. GOT2, the mitochondrial isoenzyme is...

E4319 | Aspartate Aminotransferase AST Human Elisa Kit DataSheet

E4320 | Aspartate Aminotransferase AST Mouse Elisa Kit DataSheet

K753 | Aspartate Aminotransferase AST or SGOT Activity Colorimetric Assay Kit DataSheet

E4321 | Aspartate Aminotransferase AST Rat Elisa Kit DataSheet

K552 | Aspartate Colorimetric/Fluorometric Assay Kit DataSheet

Aspterric acid is an antibiotic that acts as a plant growth regulator.Aspterric acid is an antibiotic that acts as a plant growth regulator.B2233 | Aspterric acid DataSheetAlternate Name/Synonyms:...

Astaxanthin is a potent antioxidant carotenoid and free radical scavenger. Reduces oxidative stress. Anticancer compound. Anti-inflammatory. Blocks NF-κB activation. Anti-hypertensive. Cardiovascular...

Astemizole is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG potassium channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole shows synergistic...

Astilbin is a flavonoid that displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. It inhibits cisplatin-induced increases in apoptosis and accumulation of reactive...

Astragalin is a flavonoid isolated from leaves of persimmon, green tea seeds, wine and American pokeweed. It shows anti-inflammatory and anti-oxidant activity. It dose-dependently (20-80 µg/ml)...

AT-56 is a selective, competitive, and highly bioavailable inhibitor of L-PGDS (lipocalin-type prostaglandin D synthase) (Ki = 75 µM). It inhibits the production of PGD2 by L-PGDS purified from human...

AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It...

AT13148 is a potent, ATP-competitive multi-AGC kinase inhibitor that displays antitumor activity. AT13148 blocks AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation inducing concentration...

AT-13387 is a synthetic, orally bioavailable and small-molecule inhibitor of heat shock protein 90 (Hsp90) with IC₅₀ value of 18 nM in A375 cells. Hsp90 acts as a “molecular chaperone” stabilizing...

AT-406 is a potent inhibitor of IAP (inhibitor of apoptosis protein) family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological...

AT-7519 is a potent CDK inhibitor with potential antineoplastic activity. AT-7519 displays potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines, and the mechanism of...

AT7867 is a potent inhibitor of Akt isoforms Akt1, 2, and 3 (IC₅₀s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC₅₀s = 85 and 20 nM, respectively), but is without...

A pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM)...

Ataciguat is an anthranilic acid derivative that activates the oxidized (heme-free) form of soluble guanylate cyclase (sGC) (EC₅₀= 0.5-10 µM in purified bovine lung or crude human corpus cavernosum...

Atazanavir is a potent inhibitor of HIV protease (Ki of 2.66 nM). Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of...

5070 | ATG16 Antibody (Center) DataSheet

5065 | ATG9B Antibody (CT) DataSheet

3814BP | ATGL Blocking Peptide DataSheetAntibody Target: ATGL Accession #: AAW81962Gene ID: 57104Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

3814 | ATGLAntibody DataSheet

Atglistatin is a potent, and selective inhibitor of adipose triglyceride lipase (ATGL) the rate limiting enzyme involved in fatty acid mobilization and prevention of lipolysis. It does not inhibit...

ATM Antibody | 3813

A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600,...

A cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase (IC₅₀ = 154 nM) a rate limiting enzyme in cholesterol synthesis. Blocks the...

Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P...

K354 | ATP Colorimetric/Fluorometric Assay Kit DataSheet

A 100 mM solution of ATP in de-ionized water.ATP Solution (100 mM) is a 100 mM solution of ATP in de-ionized water.2121 | ATP Solution (100 mM) DataSheetAlternate Name/Synonyms: Adenosine...

ATP Sulfurylase (EC No. EC2.7.7.4) catalyzes the first committed step in incorporating inorganic SO42- by converting ATP to adenylyl sulfate and pyrophosphate for the incorporation of inorganic SO42-...

K417 | ATPase Activity Assay Kit Colorimetric DataSheet

ATPase Activity Assay Kit II (Colorimetric) | K2099-100Description: ATPase (Adenosine Triphosphatase; EC 3.6.1.3) are a class of enzymes that catalyze the hydrolysis of adenosine triphosphate (ATP)...

Synthetic. Originally isolated from Penicillium sp. strain. An antibiotic and antifungal agent. Potent and specific mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor and...

3767 | ATR Antibody DataSheet

Atractylenolide I is a sesquiterpene that displays diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced...

Atractyloside is an extremely toxic glycoside isolated from thistles. It blocks mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di-...

Atuveciclib (BAY-1143572) is a potent and selective CDK9/P-TEFb inhibitor (IC₅₀ = 6 nM for CDK9/CyclinT1); displays >150-fold selectivity over CDK1/2/3/5/6/7 (IC₅₀ >800 nM). Exhibits anticancer...

AUDA | B3371Description: AUDA is an inhibitor of soluble epoxide hydrolase (sEH) (displaying IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. Produces a hypotensive effect...

An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages...

Aurantimycin A is a depsipeptide antibiotic that acts as a C5a antagonist. Active against Gram-positive bacteria. Displays anti-inflammatory and nematocide activity. Also an antiulcer agent...

Inhibits apoptosis in various cell types induced by a variety of factors. Potent inhibitor of DNA topoisomerase II in vitro and protein-nucleic acid interactions. Stimulates the tyrosine...

Isolated from Streptomyces sp. K06-0806. Protein biosynthesis inhibitor by binding to elongation factor Tu (EF-Tu). Effective against streptococcus pyogenes infections. It may promote growth in...

A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B,...

K449 | Autophagy/Cytotoxicity Dual Staining Kit Cell-Based DataSheet

Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.Autophinib is a...

AV-412 is a dual EGFR/ErbB2 kinase inhibitor with IC₅₀ values of 43 nM and 282 nM, respectively. Displays anticancer activity.AV-412 is a dual EGFR/ErbB2 kinase inhibitor with IC₅₀ values of 43 nM...

Avapritinib is an inhibitor of oncogenic KIT and PDGFRA mutations. The KIT receptor belongs to the class III receptor tyrosine kinase (RTK) family. Avapritinib potently inhibits the activation loop...

Avasimibe is an orally bioavailable inhibitor of the acyl coenzyme A: cholesterol acyltransferase (ACAT) (IC₅₀ = 60 nM). Avasimibe also inhibits major drug metabolizing enzymes such as CYP2C9 (IC₅₀ =...

Avibactam (NXL104) is a potent inhibitor of class A and C serine β-lactamases, including KPC carbapenemases. NXL104 quantitatively inhibits BlaC, the only chromosomally encoded β-lactamase from...

The avidin coated plates utilizes high absorbance 96-well plates coated with saturated concentration of highly pure avidin under optimized conditions. Plates were then pre-blocked with ’s Unique...

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR) receptor tyrosine kinase. It inhibits EGFR L858R/T790M double mutations with an IC₅₀ value...

AVL-292 is a potent, selective inhibitor of Bruton’s Tyrosine Kinase (BTK) (IC₅₀ = 0. 5 nM) with potential antineoplastic activity.AVL-292 is a potent, selective inhibitor of Bruton’s Tyrosine Kinase...

AVN-944 is a potent inosine 5-monophosphate dehydrogenase (IMPDH) inhibitor that displays anticancer activities. AVN-944 inhibits the growth of human prostate cancer cells by inducing cell cycle...

AX-024 is a T cell receptor (TCR) inhibitor. An orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC₅₀ = 1 nM). By modulating TCR...