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Abscisic acid is a plant hormone and growth regulator that is involved in several physiological mechanisms including seed dormancy, leaf abscission, stomatal movement, and plant stress responses. In...

Cell-permeable. The inactive enantiomer of (-)-Blebbistatin (Cat. No. 2406), a selective inhibitor of non-muscle myosin II ATPases.(+)-Blebbistatin is an inactive enantiomer of (-)-Blebbistatin (Cat...

(+)-cis-Diltiazem hydrochloride is an antihypertensive and cardioprotective agent and an inhibitor of L-type Ca²⁺ channels.(+)-cis-Diltiazem hydrochloride is an antihypertensive and cardioprotective...

A potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (Ki = 30.5 nM) that acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+...

A L-type Ca²⁺-channel activator (EC₅₀ = 17.3 nM). In combination with BIX01294 (Cat. No. 1678-5, 25), enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.(+-)-Bay K 8644 is a...

(-)-6-Azauridine 2’,3’, 5’-triacetate is a prodrug of the antiviral drug 6-Azauridine (Cat. No. B1024).(-)-6-Azauridine 2’,3’, 5’-triacetate is a prodrug of the antiviral drug 6-Azauridine (Cat. No...

Arctigenin is a lignan found in the root of A. lappa. It displays antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt...

Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro...

Deguelin is a naturally occurring flavonoid that displays potent antiproliferative, antimetastatic, and apoptotic activity against several cancers both in vitro and in vivo. deguelin induces cell...

A polyphenol flavonoid that displays antitumor and antioxidant properties. Inhibits telomerase and DNA methyltransferase (DNMT) and blocks the activation of EGF receptors and HER-2 receptors. Also...

S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα)...

Cell-permeable. A protein kinase C (PKC) activator and a tumor promoter. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.(-)-Indolactam is a protein kinase C...

Cell-permeable. A useful negative control for the BET bromodomain inhibitor (+)-JQ1 (Cat.No.2070). (−)-JQ1 enantiomer has no appreciable affinity to BET bromodomains, whereas enantiomerically pure...

A less active enantiomer of the NMDA receptor antagonist, (+)-MK-801 (Cat. No. B2326)(-)-MK-801 maleate is a less active enantiomer of the NMDA receptor antagonist, (+)-MK-801 (Cat. No. B2326)B2327 |...

(-)-p-Bromotetramisole oxalate is a potent alkaline phosphatase inhibitor. Strongly activates cystic fibrosis conductance regulator (CFTR) chloride channels by inhibiting a membrane associated...

Quinpirole is a dopamine D2 receptor agonist with Ki values of 4.8 nM, 24 nM, 30nM and 1900 nM at D2, D3, D4 and D1 receptors respectively. Quinpirole inhibits single pulse dopamine overflow in a...

(2R,6R)-Hydroxynorketamine hydrochloride is a ketamine metabolite that enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases...

4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen (Cat. No. 1551) displaying more potent estrogen agonist/antagonist activity than the parent drug tamoxifen. Also...

R-(+)-Etomoxir is a carnitine palmitoyltransferase I (CPT1) inhibitor which is required for the oxidation of long chain acyl CoA esters. It inhibits β-oxidation in mitochondria and shown to inhibit...

R-Bicalutamide is a first-generation antiandrogen that inhibits androgen action by competitively binding to the androgen receptor (AR). With other anti-androgens, R-bicalutimide decreases levels of...

(R)-Perharidine-1 is a potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer . Also acts as a casein kinase 1 (CK1δ/ε) inhibitor. Inhibits the...

(R,R)-Hymeglusin is a specific and irreversible inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase in vitro and in vivo by covalently modifying the active Cys129 residue of the...

Cell-permeable. An analog of thalidomide that was originally found based on its ability to effectively inhibit tumor necrosis factor production. Lenalidomide is 50,000 times more potent than...

Cell-permeable. A Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC₅₀ = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.(R,S)-Rolipram is a selective inhibitor of...

Potent and selective CYP2C19 inhibitor ( IC50 = 1.3 μM)Potent and selective CYP2C19 inhibitor2920 | (S)-(+)-N-3-Benzylnirvanol DataSheetAlternate Name/Synonyms:...

(S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar...

(S)-crizotinib is a low nanomolar inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase (MTH1 or NUDT1) whereas the (R)-enantiomer shows IC₅₀ values in the micromolar range. MTH1 aids in...

(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus...

H-1152 dihydrochloride is a potent, cell permeable, specific, ATP-competitive inhibitor of Rho-kinase (ROCK) (Ki = 1.6 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63,...

(Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen (Cat. No. 1551); acts as a potent estrogen receptor antagonist. Displays more potency than the parent compound. Also activates intein-linked...

(Z)-Guggulsterone is a synthetic form of the guggul tree plant steroid that displays an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X...

Cell-permeable. A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species...

(±)-Eriodictyol is a natural flavonoid with potential antioxidation activity. Eriodictyol Inhibits proliferation, metastasis and induces apoptosis of glioma cells via PI3K/Akt/NF-κB Signaling Pathway...

Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum...

Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic...

(±)-β-Hydroxybutyrate is a ketone body which accumulates in blood during fasting when the liver switches to fatty acid oxidation or in Diabetic Ketoacidosis. It is an inhibitor of class I histone...

(−)-Huperzine A is a potent and reversible inhibitor of acetylcholinesterase. It shows an IC₅₀ value of 82 nM against acetylcholinesterase in the rat cortex in vitro. It also acts as an antagonist of...

1 kb DNA LadderM1157 | 1 kb DNA Ladder DataSheetSort Name: 1 kb DNA LadderLabel Name: 1 kb DNA LadderTaglines: 1 kb DNA LadderProduct Highlights: 1 kb DNA LadderPackaging: 500 µl/100 loads

1,10-Phenanthroline is a metal chelator and inhibitor of metalloproteases. 1,10-Phenanthrine acts as a fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa...

1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4...

K684 | 1,5-Anhydroglucitol Uptake Assay Kit Cell-Based DataSheet

1,5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC₅₀ = 0.39 μM). It has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. Also...

Cell-permeable. A Potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β) inhibitor (IC₅₀ = 18 nM).1-Azakenpaullone is a potent and ATP-competitive GSK-3β (glycogen synthase kinase-3β)...

1-EBIO is an activator of Ca2+- and cAMP-sensitive K+ channels. It stimulates a sustained Cl- secretory response with an EC₅₀ of 490 μM. It induces cardiogenesis of pluripotent stem cells.1-EBIO is...

M4VP is an excellent thiol scavenging agent at neutral pH. Useful in GSH/GSSG assays.M4VP is an excellent thiol scavenging agent at neutral pH. Useful in GSH/GSSG assays.2443 |...

1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Inhibits multiple tyrosine kinase targets, such as v-Src (IC50...

10-Deacetylbaccatin III is a precursor in the semisynthetic synthesis of paclitaxel; acts as an inhibitor of microtubule assembly (IC₅₀s = 23 and 0.9 µM for porcine brain and Physaram microtubules,...

10-Hydroxycamptothecin is a potent topoisomerase I inhibitor. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound (Cat. No. 1039)...

100 bp DNA LadderM1158 | 100 bp DNA Ladder DataSheetSort Name: 100 bp DNA LadderLabel Name: 100 bp DNA LadderTaglines: 100 bp DNA LadderProduct Highlights: 100 bp DNA LadderPackaging: 500 µl/100 loads

10058-F4 is a c-Myc inhibitor that inhibits the c-Myc-Max associationn and function. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse...

The 10 Kd Spin Columns are disposable ultrafiltration devices for the concentration of biological samples. Maximum initial sample volume 500 µl. They can be used in either a swing bucket or fixed...

Buffer for use with the ’s Annexin V-FITC (Cat.# 1001-1000), Annexin V-Cy3 (Cat.# 1002-1000), Annexin V-Cy5 (Cat.#1013-1000), Annexin V-EGFP (Cat.# 1004-1000), Annexin V-PE (1014-1000), Annexin...

Red Blood Cell Lysis buffer for quick removal of RBC from whole blood, tissues and tumor cells. 10X solution makes 1L of 1X final working buffer.5831 | 10X Red Blood Cell Lysis Buffer DataSheetSort...

Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC₅₀ = 6nM). Blocks the in vivo phosphorylation of the microtubule-binding protein tau...

12-Deoxywithastramonolide is a withanolide found in W. somnifera roots that displays anti-inflammatory activity, reducing TNF-α and increasing IL-10 production in mice 12-Deoxywithastramonolide also...

14-3-3 monoclonal Antibody

Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly...

K503 | 15-PGDH Inhibitor Screening Kit Fluorometric DataSheet

A semi-synthetic derivative of Geldanamycin (Cat. No. 1564-1,5) that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2...

A water-soluble analog of 17-AAG (Cat. No. 1774-1,5) that displays better stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Binds specifically...

E4345 | 17-Hydroxyprogesterone Elisa Kit DataSheet

17β-Hydroxywortmannin is an analog of wortmannin (Cat. No. 1670) that irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC₅₀ =...

Red Blood Cell Lysis buffer for quick removal of RBC from whole blood, tissues and tumor cells.5830 | 1X Red Blood Cell Lysis Buffer DataSheetSort Name: 1X Red Blood Cell Lysis BufferLabel Name: 1X...

2',3',5'-triacetyl-5-Azacytidine is an oral prodrug form of 5-Azacytidine. 5-Azacytidine is an inhibitor of DNA methyltransferase, which can reverse epigenetically silenced genes...

2’, 5’- Dideoxyadenosine is a cell-permeable inhibitor of adenylate cyclase (IC₅₀ = 2.7 µM). Inhibits growth and causes cell differentiation (1.5 µM) in K562 cells.2’, 5’- Dideoxyadenosine is a...

A DNA methyltransferase (DNMT) inhibitor. Acts as a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP (FdUMP).2'-deoxy-5-fluorocytidine is a DNA methyltransferase...

6-Thio-dG induces telomere dysfunction in telomerase-positive human cancer cells and hTERT-expressing human fubroblasts, but not in telomerase-negative cells. Treatment with 6-thio-dG results in...

2,4-Pyridinedicarboxylic Acid is an inhibitor of histone lysine demethylases and 2-oxoglutarate oxygenases. It structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus inhibiting a range of...

2,7-Dichloro-dihydrofluorescein diacetate is a cell-permeable, fluorescent ROS (Reactive Oxygen Species) indicator that becomes fluorescent when oxidized. 2',7'-dichlorodihydrofluorescein diacetate...

A membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP₃) receptor antagonist (IC₅₀ = 42 μM).2-APB is a membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP₃) receptor antagonist (IC₅₀ = 42...

2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid G-protein coupled receptors (CB1 and CB2) with Ki values of 472 nM and 1400 nM respectively...

2-Bromopalmitic acid is a fatty acid oxidation inhibitor. It inhibits carnitine palmitoyltransferase-1 (CPT1) and is also an inhibitor of protein palmitoylation. It significantly increases retinoic...

2-Chloroadenosine is an adenosine receptor agonist. It binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1900 nM, respectively. It significantly decreases seizures in a rat...

2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P...

2-Guanidinobenzimidazole is an inhibitor of voltage-gated proton channel Hv1. It inhibits Hv1 proton conduction (10 μM-200 μM) by binding to the voltage-sensing domain. Inhibition of excessive Hv1...

2-Hexyl-4-Pentynoic Acid is an inhibitor of histone deacetylases (HDACs). It is a derivative of Valproic acid. It inhibits HDAC activity with an IC₅₀ of 13 μM, compared to an IC₅₀ of 398 μM for...

2-Hydroxflutamide is a metabolite of flutamide that acts as an AR antagonist. Also inhibits the proliferation of estradiol-induced growth of MCF-7 breast cancer cells.2-Hydroxflutamide is a...

E4635 | 2-Methoxyestradiol 2-ME2 Elisa Kit DataSheet

2-Methoxyestradiol (2-ME) is major estradiol metabolite that acts as a potent inhibitor of endothelial cell proliferation and angiogenesis. It displays little affinity for classical estrogen...

2-Methyl-5-hydroxytryptamine is a 5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM). Recently, this has been used as one of the components of the chemical cocktails used for...

K682 | 2-NBDG Glucose Uptake Assay Kit Cell-Based DataSheet

2-NBDG is a fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues. 2-NBDG can be used in real-time confocal, high-resolution,...

2-Nitro-5-thiocyanatobenzoic acid is used to cyanylate proteins and to specifically cleave the amino-terminal peptide bond of cysteine residues. Also, acts as a hydratase inhibitor...

K778 | 2-Phosphoglycerate Colorimetric/Fluorometric Assay Kit DataSheet

20-Hydroxyecdysone (20E) is an important steroid hormone that controls embryonic development, molting, metamorphosis, and reproduction in members of the phylum Arthropoda. It acts through a...

An important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain. It is an endogenous agonist of the nuclear receptor LXR. It has been shown to induce cell death in neuroblastoma...

27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and...

The 2X Reaction Buffer was optimized for caspase activity assay reactions. The buffer provides an economic reagent for researchers who perform large amount of caspase activity assays.1068 | 2X...

3,3',5’-Triiodo-L-thyronine (Reverse T3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ...

Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic...

3,6-Dihydroxyflavone is a flavanoid which shows anticancer activity. It suppresses breast carcinogenesis by upregulation of miR-34a and downregulation of miR-21 at a concentration of 20 μM...

3-Acetyl-11-keto β boswellic acid (AKBA) is a naturally occurring pentacyclic triterpene that acts as an antiangiogenic and neuroprotective agent, reducing the impact of proliferative retinopathies,...

A more potent inhibitor of nNOS than 7-nitroindazole (Cat. No. 2360) in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC₅₀ values for inhibition of rat nNOS, bovine eNOS, and...

3-Bromopyruvic acid is a hexokinase inhibitor that has been shown to abolish ATP production and cause severe depletion of cellular ATP. It displays potent cytotoxic activity against cancer cells with...

3-Cyano-7-ethoxycoumarin is a fluorogenic substrate for cytochrome P450. It is metabolized to 3-cyano-7-hydroxycoumarin with an excitation/emission maxima of 408/450 nm, respectively. It can be used...

3-Deazaadenosine (3-DZA) is an inhibitor of SAH (S-adenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis,...

A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of...

A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of...

Commonly used as a specific inhibitor of autophagic sequestration. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K)...

A plant and fungal toxin, 3-nitropropionic acid acts as an irreversible inactivator of succinate dehydrogenase. Selectively inhibits succinic dehydrogenase complex (Complex II) in the mitochondrial...