(-)-JQ1 | 2384

Cell-permeable. A useful negative control for the BET bromodomain inhibitor (+)-JQ1 (Cat.No.2070). (−)-JQ1 enantiomer has no appreciable affinity to BET bromodomains, whereas enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively.

(-)-JQ1 is a useful negative control for the BET bromodomain inhibitor (+)-JQ1 (Cat.No.2070).

2384 | (-)-JQ1 DataSheet

Alternate Name/Synonyms: t-Butyl-2-((6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1268524-71-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅ClN₄O₂S

Molecular Weight: 456.99

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A negative control for (+)-JQ1 (Cat. No. 2070).

MDL Number: N/A

PubChem CID: 49871818

SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C

InChi: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1

InChi Key: DNVXATUJJDPFDM-QGZVFWFLSA-N