(-)-Epigallocatechin gallate | 1841

A polyphenol flavonoid that displays antitumor and antioxidant properties. Inhibits telomerase and DNA methyltransferase (DNMT) and blocks the activation of EGF receptors and HER-2 receptors. Also potently and specifically inhibits chymotrypsin-like activity of the proteasome in vitro (IC₅₀= 86-194 nM) and in vivo (IC₅₀ =1 -10 µM).

(-)-Epigallocatechin gallate is a polyphenol flavonoid that displays antitumor and antioxidant properties. Inhibits telomerase and DNA methyltransferase (DNMT) and blocks the activation of EGF receptors and HER-2 receptors.

1841 | (-)-Epigallocatechin gallate DataSheet

Alternate Name/Synonyms: EGCG; (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)

Appearance: Off-white to yellow solid

Formulation: N/A

CAS Number: 989-51-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₈O₁₁

Molecular Weight: 458.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO or EtOH

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antioxidant

MDL Number: MFCD00075940

PubChem CID: 65064

SMILES: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

InChi: InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

InChi Key: WMBWREPUVVBILR-WIYYLYMNSA-N