(Z)-Guggulsterone | B2773

(Z)-Guggulsterone is a synthetic form of the guggul tree plant steroid that displays an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).

(Z)-Guggulsterone is a synthetic form of the guggul tree plant steroid that displays an ability to lower LDL cholesterol and triglyceride levels. Acts as a selective antagonist of farnesoid X receptor (FXR) and inhibits FXR transactivation (IC50 = 10 µM in the presence of 100 µM chenodeoxycholic acid). Does not activate or inhibit transactivation of liver X receptor α (LXRα), peroxisome proliferator activated receptor γ (PPARγ), or retinoid X receptor α (RXRα).

B2773 | (Z)-Guggulsterone DataSheet

Alternate Name/Synonyms: 4,17(20)-trans-Pregnadiene-3,16-dione,(17Z)-Pregna-4,17(20)-diene-3,16-dione

Appearance: Off-white solid

Formulation:

CAS Number: 39025-23-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₈O₂

Molecular Weight: 312.45

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective farnesoid X receptor (FXR) modulator

MDL Number: MFCD01310757

PubChem CID: 6450278

SMILES: CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

InChi: InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1

InChi Key: WDXRGPWQVHZTQJ-OSJVMJFVSA-N