3,3'-Diindolylmethane | 2150

Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic properties in animal and in in vitro models of cancer. Also acts a selective and potent inhibitor of cancer stem cells, and HDAC activity in prostate cancer cells. Recently, it has been shown that DIM induces apoptosis in ovarian cancer cells by inhibiting JAK2/STAT3.

Diindolylmethane (DIM) is a natural compound present in food plants of the Brassica genus, including broccoli, cabbage, Brussels sprouts, cauliflower and kale. Displays antitumor and proapoptotic properties in animal and in in vitro models of cancer. Also acts a selective and potent inhibitor of cancer stem cells, and HDAC activity in prostate cancer cells.

2150 | 3,3'-Diindolylmethane DataSheet

Alternate Name/Synonyms: 3,3’-Methylenediindole; DIM

Appearance: White to Off-white Solid

Formulation: N/A

CAS Number: 1968-05-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₄N₂

Molecular Weight: 246.31

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of cancer stem cells

MDL Number: MFCD00195766

PubChem CID: 3071

SMILES: C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43

InChi: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2

InChi Key: VFTRKSBEFQDZKX-UHFFFAOYSA-N