(-)-Blebbistatin | 2406

Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while weakly inhibiting smooth muscle myosin (IC₅₀ = 80 μM). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.

(-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPases.

2406 | (-)-Blebbistatin DataSheet

Alternate Name/Synonyms: 1,​2,​3,​3a-​tetrahydro-​3aS-​hydroxy-​6-​methyl-​1-​phenyl-​4H-​Pyrrolo[2,​3-​b]quinolin-​4-​one; (S)-Blebbistatin

Appearance: Yellow solid

Formulation: N/A

CAS Number: 856925-71-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆N₂O₂

Molecular Weight: 292.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A selective non-muscle myosin II ATPases inhibitor

MDL Number: MFCD08460907

PubChem CID: 5287792

SMILES: CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O

InChi: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1

InChi Key: LZAXPYOBKSJSEX-GOSISDBHSA-N