(S)-(-)-Bay K 8644 | B3011

(S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar concentrations in guinea-pig ventricular myocytes. The (−)-enantiomer has vasoconstricting and positive inotropic properties. (−)-Bay K 8644 also enhances the force of contraction and prolongs the action potential duration measured at 50% of repolarization in guinea-pig papillary muscles at normal resting potential. (−)-S-BAY K 8644 impairs rotarod and motor activity with an ED₅₀ value of 0.5 mg/kg in mice. It enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.

(S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar concentrations in guinea-pig ventricular myocytes. The (−)-enantiomer has vasoconstricting and positive inotropic properties. (−)-Bay K 8644 also enhances the force of contraction and prolongs the action potential duration measured at 50% of repolarization in guinea-pig papillary muscles at normal resting potential. (−)-S-BAY K 8644 impairs rotarod and motor activity with an ED₅₀ value of 0.5 mg/kg in mice. It enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.

B3011 | (S)-(-)-Bay K 8644 DataSheet

Alternate Name/Synonyms: (S)-(-)-BAY K 8644; (-)-(S)-BayK8644; (-)-BAY-k-8644; methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

Appearance: Yellow solid

Formulation:

CAS Number: 98625-26-4

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₆H₁₅F₃N₂O₄

Molecular Weight: 356.3

Cell-Permeable?: TRUE

Purity: >98%

Solubilities: ~20 mg/ml in DMSO and DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An L-type Ca channel agonist

MDL Number: MFCD00153769

PubChem CID: 6603728

SMILES: CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

InChi: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1

InChi Key: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N